Type 2 Procollagen Gene Mutation in Osteoarthritis / 대한류마티스학회지
The Journal of the Korean Rheumatism Association
;
: 27-32, 1997.
Article
in Korean
| WPRIM
| ID: wpr-55963
ABSTRACT
OBJECTIVES:
Human osteoarthritis is a heterogeneous and multifactorial disease characterized by the progressive deterioration of the cartilage of diarthrodial joints. In some instances, there is an identifiable cause, such as trauma or congenital malformation, but, mostly the etiology remains unknown. Since familial aggregation is seen, genetic factors may be important, particularly in osteoarthritis of the hand.METHODS:
Blood samples from patients and controls were obtained for DNA analysis. Exon 31 of type II procollagen gene was amplified by polymerase chain reaction, and screening for the mutation was undertaken using a restriction enzyme digestion (Dsa I).RESULTS:
The patients phenotype represented typical, but earlyonset and family history, osteoarthritis. No mutation in exon 31 of type II procollagen gene could be identified.CONCLUSION:
Screening of the 31 exon did not, however, reveal any mutation. It needs further evaluation in other sites of type II procollagen genes.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osteoarthritis
/
Phenotype
/
DNA
/
Cartilage
/
Mass Screening
/
Polymerase Chain Reaction
/
Exons
/
Procollagen
/
Collagen Type II
/
Digestion
Type of study:
Prognostic study
/
Screening study
Limits:
Humans
Language:
Korean
Journal:
The Journal of the Korean Rheumatism Association
Year:
1997
Type:
Article
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