Lipopolysaccharide: Basic Biochemistry, Intracellular Signaling, and Physiological Impacts in the Gut
Intestinal Research
;
: 90-95, 2014.
Article
in English
| WPRIM
| ID: wpr-55971
ABSTRACT
Lipopolysaccharide (LPS), a main constituent of Gram-negative bacterial membrane, specifically activates Toll-like receptor 4, leading to the production of pleiotropic cytokines/chemokines which in turn regulate inflammatory and innate and subsequent adaptive immune responses. Given that human gut harbors a large collection of commensal bacteria, LPS released by gut microbes is able to make the great impact on gut homeostasis through the intracellular signaling pathways engaged by host-microbial interaction. Emerging evidence indicates that LPS in the gut has a potency to elicit the pathogenesis of intestinal inflammatory diseases such as inflammatory bowel disease and necrotizing enterocolitis. In this review, we discuss the current understanding of the basic biochemistry of LPS, LPS-induced intracellular signaling, and physiological impacts of LPS in the intestine.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Bacteria
/
Biochemistry
/
Inflammatory Bowel Diseases
/
Lipopolysaccharides
/
Enterocolitis, Necrotizing
/
Toll-Like Receptors
/
Toll-Like Receptor 4
/
Homeostasis
/
Intestines
/
Membranes
Limits:
Humans
Language:
English
Journal:
Intestinal Research
Year:
2014
Type:
Article
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