The relationship between sigmoid colon propagating motility and cholecystokinin and motilin in patients with irritable bowel syndrome / 中国实用内科杂志

ABSTRACT

Objective To investigate the relationship between the sigmoid colon propagating contractions and the gut hormones cholecystokinin(CCK)and motilin(MTL)in the patients with irritable bowel syndrome(IBS),and to reveal the gut hormones' modulation to the sigmoid colon motility.Methods Twenty diarrea-predominent IBS patients(D-IBS),and sex/age matched 20 constipation-predominent IBS patients(C-IBS)and 15 healthy volunteers were enrolled in the study.From June 2005 to Mar.2006,the high amplitude propagating waves and loger time of the sigmoid colon was measured by means of a liquid-perfused capillary tube connected to a computer.Meanwhile,the concentrations of CCK,MTL of blood plasma and sigmoid colon mucosa were tested by means of immunoassay technology.Results The D-IBS group had higher amplitude of the sigmoid colon propagating waves and their time percentage than that of the C-IBS group and the control group(P