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Bioequivalence of Metoprolol Tartrate Tablets in healthy volunteers / 中国临床药理学与治疗学
Article in Chinese | WPRIM | ID: wpr-559950
Responsible library: WPRO
ABSTRACT

AIM:

To study the bioequivalence of domestic and imported Metoprolol Tartrate Tablets in Chinese healthy volunteers.

METHODS:

According to the rule published by SFDA,the serum concentration of 20 selected volunteers among 18 to 40 years old was determined by HPLC-fluorescence detection after giving domestic and imported Metoprolol Tartrate Tablets 0.1g,and the pharmacokinetic parameters were calculated by DAS software.

RESULTS:

The method of HPLC-fluorescence detection to study the pharmakokinetics of Metoprolol Tartrate was sensitive,reliable,accurate and reasonable.The main pharmakokinetics parameters of domestic and imported Metoprolol Tartrate Tablets were T_(max)(1.11)?(0.36 h) and(1.39)?(0.65 h) respectively;C_(max)(269.20)?(87.15)(?g?L~(-1)) and(262.03)?(75.52)(?g?L~(-1)) respectively;AUC_(0-12h)(1088.91)?(510.52)(?g?L~(-1)?h) and(1098.29)?5(55.14)(?g?L~(-1)?h) respectively.The relative bioavailability of domestic Metoprolol Tartrate Tablets was(100.09)%.

CONCLUSION:

The domestic and imported Metoprolol Tartrate Tablets was bioequivalents.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Clinical Pharmacology and Therapeutics Year: 2004 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Clinical Pharmacology and Therapeutics Year: 2004 Type: Article