Effects of ozone-stress on E-cadherin expression in human bronchial epithelial cells / 中国临床药理学与治疗学

ABSTRACT

AIM: To explore the expression of E-cadherin(E-cd) in the human bronchial epithelial cells(HBECs) and their role in the damage and injury of the airway.METHODS: The E-cd protein expression and the Ecd mRNA of HBECs were determined by immunocytochemistry analysisand RT-PTR analysis,respectively.RESULTS: Ozone-stress caused a decrease in the HBECs membrane E-cd expression and an increase the cytoplasmic E-cd expression(P(0.05)).CONCLUSION: E-cd is distributed on HBECs.O_3-stress decreases the membrane E-cd expression but increases the cytoplamic E-cd expression.The change of E-cd expression may mediate HBECs injuries induced by O_3-stress.