Analysis of the Use and Reasonable Researching of Anti-infectious Medicine in Patients in ICU / 医学研究杂志

ABSTRACT

Objective Through an investigation and analysis of the using situation of anti-infectious medicine for the patients of ICU in hospital,to provide guidance for the rational antimicrobial use in clinic and strengthen the level of clinical doctors′reasonable use of the medicine. Methods The anti-infectious medicine used for the patient of ICU in hospital is analysed in respect to defined daily dose (DDD),drug utilization index(DUI). Results An overwhelming majority of anti-infectious medicine′s utilization is reasonable,but 52.4% of the anti-infectious medicine is over the demand of DUI≤1.The result of the DDDsthe Chemical Synthesis′s capacity(32.14%),the aminoglycosides(13.62%),the ?-Lactams and their?-Lactamase inhibitors(13.20%),the antifungal agents(12.66%),the cephalosporins(9.52%).The fuloroquinolones,the third and the forth cephalosporins and the carbapenems are used broadly.The medicine's unit-rate gets 92%,and six unit is the most of all.It can be seen from the category and distribution of the use of anti-infectious medicine that the cephalosprins is the first.The antimicrobial resistance is developed rapidly.The antimicrobial resistance of levofloxacin is 54.45%,then gentamicin is 51.78% and ampicillin,ciprofloxacin,cefazolin,ceftriaxone,SMZco are more than 40%. Conclusions In choosing the dose with the normal regulation(not the dose of indication),doctors consider less for the factors such as the age,medicine interacion,dose of indication,etc.Using the broad-spectrum usually led to many universal phenomenon such as antimicrobial resistance,bacteria migrated and antimycotic infection,etc.That makes double infection(32%) which can't be neglected.The theory of medicinal economics is less used in the clinic practices.