Vitamin K in treating secondary osteoporosis to nephrotic syndrome in children / 第三军医大学学报

ABSTRACT

Objective To explore the characterization of children osteoporosis and to find an effective treatment plan.Methods The children(n=62) with osteoporosis caused by nephropathy or glucocorticoid were randomized to receive vitamin K(1 mg?kg~(-1)?d~(-1)),or vitamin D(0.03 ?g?kg~(-1)?d~(-1)),or vitamin K+vitamin D from one month after hormone therapy.The markers of bone metabolism in blood and bone density were observed before and after hormone therapy.Results After 1 month after high-dose steroid administration,the bone density decreased in all children with nephrotic osteoporosis.The indexes of the children receiving vitamin K ameliorated significantly as compared with before treatment.Osteocalcin and bone specific alkaline phosphatase in blood had a positive correlation with bone density.Conclusion Osteocalcin may be regard as a bone formation index in children just as bone specific alkaline phosphatase.Vitamin K and vitamin D are of synergistic action.Vitamin K is a safe,effective and simple drug and should be used widely.