Expression of survivin and bcl-xl in non-small cell lung cancer and their relationship / 中国实用内科杂志

ABSTRACT

Objective To investigate the expression of survivin and bcl-xl in non-small cell lung cancer(NSCLC)and their relationship.Methods The NSCLC tissuechips including 32 cores were constructed and expression of survivin and bcl-xl was examined by immunohistochemical technique in 30 normal bronchial epithelium and 32 primary NSCLC.Results The positive rate of survivin and bcl-xl protein in NSCLC was 71.9% and 81.3% respectively,significantly higher than that in the normal ones(P0.05).The expression of bcl-xl protein was closely related to cell differentiation(P0.05).The over-expression of survivin and bcl-xl was positively correlated(P