Studies on the effects of antiepileptic drugs on rats′ cognitive function kindled by pentylenetetrazole / 解放军医学杂志

ABSTRACT

Objective To explore the effect of antiepileptic drugs on rats' cognitive function. Methods 70 adolescent male SD rats, weighing (201?29)g, were randomly divided into seven groups normal control group (NS), status epilepticus group (Pentylenetetrazole, PTZ), carbamazepine group (CBZ), valproate sodium group (VPA), phenytoin group (PHT), topiramate group (TPM) and lamotrigine group (LTG). All animals except those in NS group were kindled by PTZ, then they were treated with antiepileptic drugs (AEDs). Rats of all the seven groups were subjected to Morris water maze test two weeks later. Results The average time spent by the rats of TPM group was longer than that by other groups in each test (P