Molecular scanning for MODY5 mutation in Beijing population of familial early-onset type 2 diabetes / 第三军医大学学报

ABSTRACT

T,1 mutation in coding region including A513T. No target gene mutations were found in 100 controls.Conclusion No enough evidence demonstrates that the variation in or near MODY5 genes is the major cause of early-onset type 2 diabetes in Beijing population.A novel mutation of MODY5 gene was found to possibly relate to diabetes,which mechanism needs to be proved by further study of protein function.