Action of hydroxyanthroquinones from Rheum Palmatum L on jaundice model of rat induced by ANIT / 中国药理学通报

ABSTRACT

Aim To observe the action of hydroxyanthroquinones from Rheum Palmatum L on reduced jaundice and enzyme in acute jaundice model of rat induced by ANIT.Methods Wistar rats were randomized into five groups group A in which no treatment was given,group B in which ANIT was given on the eighth day,group C in which high dosage of hydroxyanthroquinones from Rheum Palmatum L was given,group D in which low dosage of hydroxyanthroquinones from Rheum Palmatum L was given,group E in which "Yinzhihuang injection" was given as positive control.Except group A and B,other groups were given corresponding drugs for 7 days and then additionally administered ANIT to induce jaundice on the eighth day.Forty-eight hours later,the rats′ blood was gained from eyes and the serum was separated.The liver functional sign,the activity of SOD,the content of MDA in serum and change in pathology of liver tissue were observed.Results Compared to group B,ALT,AST,TBIL,ALP,?-GT ,MDA of group C and E descended obviously(P0.05).Conclusion Hydroxyanthroquinones from Rheum Palmatum L has the action of reducing serum bilirubin and transaminase and improving liver tissue injury in rats of experimental Cholestasis.