Analysis of SRY Gene in 6 Cases With Sexual Abnormality / 医学研究杂志

ABSTRACT

Objective TO Provide information for clinical diagnosis and study the mechanism of sexual abnormality . Methods 6 cases of sexual abnormality were detected with PCR amplification and DNA sequencing techniques.ResultsSRY gene was positive in 45,XO male and 46,XY female whose DNA sequence of conserved region had no mutation.SRY gene was negative in 46,Xxmale.Three46,XY males with sexual abnormality showed SRY positive.Conclusions The sexual abnormality of 45,Xomale was caused by SRY positive.Conclusions The sexual abnormality of 45,XOmale was caused by SRY gene translocation .Sexual reverse infemale was caused by gene conseved region mutation but in male it might be caused by sexual related gene mutation on chromasome.