Relationship between the level of serum homocysteine and endothelial function in patients with coronary heart disease / 中国实用内科杂志

ABSTRACT

Objective To investigate the relationship between serum homocysteine(Hcy)level and endothelial function in patients with coronary heart disease(CHD).Methods A total of 209 patients having undertaken coronary angiography were enrolled in this study.The serum concentrations of homocysteine were investigated for all subjects using fluorescence polarization immunoassay.B-mode ultrasound was used to scan brachial arteries for all subjects at rest and during reactive hyperemia,and then the rates of endothelium-dependent and independent flow-mediated vasodilatation(FMD% and NTG%)of the brachial artery were calculated.Results The values of Hcy in the CHD group were higher than that in the control group(P