Study on genomic imprinting of IGF2 gene / 中国实用内科杂志
Chinese Journal of Practical Internal Medicine
;
(12)2006.
Article
in Chinese
| WPRIM
| ID: wpr-560554
ABSTRACT
Objective To study the role of genomic imprinting of IGF2 gene in the development of lung cancer.Methods The IGF2 genomic imprinting was studied among 32 patients with lung cancer and the normal lung tissues by using PCR and RFLP.Results Twelve out of the 32 patients were informative(37.5),among whom 10 exhibited biallelic expression,i.e.,LOI(83.3).The matched normal tissues from 4 of these 10 patients also showed weak biallelic expression of IGF2.Conclusion The findings indicate that the loss of IGF2 imprinting is involved in the development of lung cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Practical Internal Medicine
Year:
2006
Type:
Article
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