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THE PROTECTIVE EFFECT OF EXOGENOUS NUCLEOTIDES ON LIPOPOLYSACCHARIDE IMMUNOSTIMULATION IN MICE AND ITS MECHANISM / 营养学报
Acta Nutrimenta Sinica ; (6)2004.
Article in Chinese | WPRIM | ID: wpr-560700
ABSTRACT

Objective:

To study the protective effects of exogenous nucleotides on lipopolysaccharide(LPS)immunnostimulation and its mechanism.

Method:

Forty healthy Kunming mice were randomly divided into five groupscontrol group,nucleotides(NT)groups(4h,18h),nucleotides free(NF)groups(4h,18h).Control group and NF groups were fed with nucleotide-free diet.NT groups were fed with nucleotide-supplemented diet(0.25% nucleotides).On D 15,mice were lavaged with physiological saline(control)or LPS,and were killed 4 or 18 h later.Serum,liver,small intestine,and peritoneal macrophage were sampled in germfree state.

Results:

Hepatic Na+K+-ATPase,intestinal superoxide dismutase(SOD),serum total anti-oxidation ability,peritoneal macrophage-produced interleukin 10(IL-10)were increased,and intestinal malonaldehyde(MDA),serum alanine aminotransferase(ALT),intestinal myeloperoxidase(MPO),peritoneal macrophage-produced interleukin 1(IL-1)were decreased with nucleotides supplement.

Conclusion:

Exogenous nucleotides can help to maintain oxidation-antioxidation and inflammation-antiinflammation balance,and protect mice from injury under LPS immunostimulation.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Acta Nutrimenta Sinica Year: 2004 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Acta Nutrimenta Sinica Year: 2004 Type: Article