Influence of gene polymorphism of aldosterone synthese gene CYP11B2(-344T/C)on antihypertensive response to Valsartan in Han nationality essential hypertension patients in Beijing / 中国实用内科杂志
Chinese Journal of Practical Internal Medicine
;
(12)2001.
Article
in Chinese
| WPRIM
| ID: wpr-560773
ABSTRACT
Objective To evaluate the association between gene polymorphism of aldosterone synthese gene CYP11B2(-344T/C)and essential hypertension and to observe the antihypertensive response to Valsartan in Han nationality in Beijing.Methods Polymerase chain reaction was used to detect the polymorphism of aldosterone synthese gene CYP11B2(-344T/C)in 345 hypertensive patients(EH)and 157 normotensive controls(NE)from Aug.1999 to Oct.2003.Clinical blood pressure and biochemical index were also detected.Blood pressure was repeated in 98 patients with Valsartan treatment for 4 weeks.Results The frequencies of CC+CT genotype of aldosterone synthese gene CYP11B2(-344T/C)polymorphism among EH was significantly higher than that among NE(P
Full text:
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Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Practical Internal Medicine
Year:
2001
Type:
Article
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