Proteasome inhibitor MG-132 inhibits myocardial reperfusion injury in rats by suppressing expression of inflammatory factors / 第三军医大学学报
Journal of Third Military Medical University
;
(24)1984.
Article
in Chinese
| WPRIM
| ID: wpr-560858
ABSTRACT
Objective To investigate the influence of proteasome inhibitor MG-132 on inflammatory factors in rat model of myocardial ischemia/reperfusion. Methods Adult Sprague-Dawley rats were divided into 4 groups. I/R group left anterior descending (LAD) coronary artery was ligated for 30 min, and then reperfused for 0, 1, 2, 6, 24 h; I/R+T group MG-132 was used for treatment, and other procedures as I/R group; Sham operation group; Sham operation+T group. At 5 min before reperfusion, MG-132 (0.75 mg/kg) was given intravenously in I/R+T group and Sham operation+T group, and normal saline for I/R group and sham operation group. The changes of myocardial ultrastructure were checked, and the protein and mRNA levels of NF-?Bp65 and TNF-?, the number of PMN, the activity of MPO and survival of each group were detected. Results As compared with Sham operation group and Sham operation+T group, the protein and mRNA levels of NF-?Bp65 and TNF-?, the number of polymorphonuclear leucocytes (PMN) and the activity of myeloperoxidase (MPO) were significantly increased in I/R group (P
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Journal of Third Military Medical University
Year:
1984
Type:
Article
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