INFLUENCE OF ANGIOTENSIN CONVERTING ENZYME INHIBITORY PEPTIDES ON THE EXPRESSION OF eNOS,iNOS,ET-1 mRNA IN HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS / 营养学报

ABSTRACT

Objective and Method: To study the influence of angiotensin converting enzyme inhibitory peptides (ACEIP) on the expression of eNOS, iNOS, ET-1 mRNA in cultured human umbilical vein endothelial cells by semi-quantitative reverse transcription-polymerase chain reaction(RT-PCR) method and then investigate its mechanism. Results: Campared with the control, the expression of ET-1 and iNOS was lower and the expression of eNOS was higer in different ACEIP groups. Conclusion: The antihyertensive function of ACEIP partly depended on the its effect to lessen the expression of ET-1,iNOS and induce the expression of eNOS in cultured human umbilical vascular endothelial cells.