HIV drug resistance and influence factors in some provinces of China / 中国实用内科杂志

ABSTRACT

Objective To prevent the prevalence of drug resistance viruses,we analyzed drug resistance mutations of HIV-1 among HIV-1 infected individuals in seven provinces of China.Methods We acquired 718 HIV-1 infected patients' treatment and compliance from questionnaires,amplified HIV-1 pol genes by RT-PCR and nest-PCR,sequenced RT and protease regions and run clustal with the subtype B consensus amino acid sequence in Stanford HIV drug resistance sequence database.Results The viral load in treated patients was obviously lower than that in untreated patients(P