Bone microstructure changes and bone BMP-2 expression in rats at early period of diabetes / 第三军医大学学报

ABSTRACT

Objective To investigate the changes of bone density,bone microstructure,bone BMP-2 expression in rats at early period of diabetes.Methods Thirty SPF 4-month-old male Wistar rats were randomly divided into 3 groups(n=10 in each group)A(fed with common forage as normal control group),B(fed with high-lipid forage and intraperitoneally injected with STZ to establish type 2 diabetes with insulin resistance),C(fed with common forage and intraperitoneally injected with STZ to establish type 2 diabetes with insulin secretion defaulting).The bone histomorphology,bone histomorphometry,bone BMP-2 expression were investigated 12 weeks later.Results As compared with group A,bone microstructure was of no obvious changes and bone BMP-2 expression was higher in group B(P