Effect of extended-release methylphenidate on the ecological executive function for attention deficit hyperactivity disorder / 北京大学学报(医学版)

ABSTRACT

Objective:To test the effect of extended-released methylphenidate(Concerta) on ecological executive function for attention deficit hyperactivity disorder(ADHD) and to evaluate the correlation between the improvement of ecological executive function and that of the core symptom of ADHD.Methods:We conducted a 4-6-week open-trial study of extended-released methylphenidate(18-54 mg/d) in 26 children with ADHD,aged 8-14 years.Ecological executive function and ADHD symptoms were ascertained by the parent form of behavior rating inventory of executive function(BRIEF),ADHD-Ⅳ rating scale and Conners short form rating scales before and after the treatment.Results:The mean item raw score of global executive composite(GEC),metacognition index(MI),working memory,monitor and inhibition subscale of BRIEF were significantly decreased after the treatment(t=2.763-3.380,P