A study on mechanisms of stigma maydis polysaccharide on weight loss in experimental animals / 中国药理学通报

ABSTRACT

Aim To study mechanisms of Stigma Maydis Polysaccharide(SMPS) on weight loss in experimental animals. Methods Observe changes of gastric discharge, intestinal peristalsis, biliary secretion, weight of gallbladder, body weight, appetite and cholecystokinin(CCK)level in plasm of rats and mice after being administrated with SMPS. Results SMPS increased the gastric residual rate of methyl orange and the intestinal propulsive rate,advanced first time black dejecta,increased the quantity of dejecta,decreased the weight of gallbladder in mice. SMPS also inhibited appetite,decreased body weight,prolonged gastric emptying,accelerated the propulsion speed of intestinal contents,promoted the biliary secretion,increased CCK level in plasm. Conclusion Mechanisms of weight loss are probably related to the increasing of CCK level in plasm and prolonging of gastric emptying,appetite inhibition, accelerating of intestinal peristalsis,the quantity increasing of dejecta.