Changes and clinical significance of serum matrix metalloproteinase in patients with chronic cardiac failure / 中国基层医药

ABSTRACT

Objective To investigate the changes and clinical significance of serum matrix metalloproteinase- 2,9(MMP-2,MMP-9)concentration in paticnts with chronic cardiac failure(CCF).Methods Concentrations of serum MMP-2,MMP-9 in patients with CCF(n=60)and in normal controls(n=50)were measured.Constructive and funcrional parameters of heart were measured by echocardiography in all patients.The relationship between con- centrations of serum MMP-2.MMP 9 and CCF was analyzed.Results Concentrations of serum MMP-2,MMP-9 in CHF were significantly higher than those in normal controls)P