Clinical Efficacy Evaluation of Leukotriene Receptor Antagonists for Treatment of Coexisting Asthma and Allergic Rhinitis in Children / 国际儿科学杂志
International Journal of Pediatrics
;
(6)2007.
Article
in Chinese
| WPRIM
| ID: wpr-561886
ABSTRACT
Objective To evaluate the efficacy of Leukotriene receptor antagonists in treatment of patients with asthma and allergic rhinitis(AR).Methods This study was a 24-week,randomized,control open trial in which 100 children,who were diagnosed as mild to severe persistent coexisting asthma and AR,were enrolled.All cases were collected from pediatric out-patient department of the First Affiliated Hospital of Guangzhou Medical College from October 1st,2005 to April 30th,2006 and were divided into three groups.Montelukast group(1 group)inhated budesonide turbuhaler and oral singulair(5mg/Qn);Intranasal corticosteroids group(2 group)inhaled budesonide turbuhaler and intranasal budesonide nasal spray(64?g/Qd);Control group(Control group)only inhaled budesonide turbuhaler.Efficacy was assessed by recording daytime and nighttime symptom scores,nasal symptom scores,the times of acute episode,the symptomfree days,the requirement for the weekly beta 2-receptor agonist and the medication scores,using a daily diary card and the recording work were repeated per fo ur weeks in totally six months.Lung function(forced expiratory volume at 1 s inpredicted normal,FEV1%) and nasal eosinophil count had been tested three timesbefore treatment,after treatment of 8th and 24th week.Results 1 group and 2 group,compared with the prior treatment(P0.05);1 group was more statistically significant than 2 group in improving FEV1(P
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Controlled clinical trial
Language:
Chinese
Journal:
International Journal of Pediatrics
Year:
2007
Type:
Article
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