Effect of Oxymatrine on Glucose、Fat and Activity of Peroxisome Proliferator Activated Receptor / 医学研究杂志

ABSTRACT

Objective To observe the effect of oxymatrine on the Absorption of carbohydrate and fat and the activity of peroxisome proliferator activated receptor ? and ?.Methods 64 masculine SD rats were randomly divided into three groups,20 sugar tolerance test,20 triacylglycero Absorption test and 24 oxymatrine effecting on triacylglycero and cholesterin test,and observed the effect of oxymatrine on glycosidase activity,blood sugar and activity of peroxisome proliferator activated receptor ? and ?.Results ① The depressant effect of oxymatrine on the activity of glycosidase was strengthened by the increased dosage.② Oxymatrine could suppress the upgraded level of blood sugar after took amylon and cane-sugar,and inhibit the upgraded level of triacylglycerol after feed by olive oil and hypso-cholesterol,but did not suppress the upgraded level of blood sugar after took glucose and hardly influence the level of high density lipoprotein cholesterol and low density lipoprotein cholesterol.③ Oxymatrine could obviously activate the activity of peroxisome proliferator activated receptor ? and ?,the activity of peroxisome proliferator activated receptor ? and ? increased gradually by the augment of the oxymatrine,and expressed evident dose-response relation.Conclusions Oxymatrine could not only directly inhibit the Absorption of triacylglycerol and depress the elevated level of postprandial triacylglycerol,but also activate peroxisome proliferator activated receptor ?,moreover possess dose-response relation.