Effect of Fiveleaf Gynostemma Herb on hyperlipoidemia and hemorheological changes in rabbits / 第三军医大学学报

ABSTRACT

Objective To study effect of Fiveleaf Gynostemma Herb on hyperlipoidemia and hemorheological changes in rabbits.Methods Forty rabbits were randomly divided as groups A(fed with high fat food plus 5 g/kg Fiveleaf Gynostemma Herb),B(high fat food plus 5 mg/kg simvastatin),C(high fat food),E(standard feedstuff).TG,TC,LDL-C,HDL-C,endothelin-1(ET-1)and hemorheological indexes(blood viscosity,plasma viscosity,erythrocyte aggregation)were checked before experiment and at 9th week after experiment.Ultramicrostructure of endothelial cells was observed.Results TG,TC and LDL-C of groups A,B and C increased gradually.TG,TC,LDL-C of groups A and B were lower than those of group C(P