Effect of non-invasive positive pressure ventilation in treatment of COPD at acute exacerbation phase combined with typeⅡrespiratory failure in 53 patients / 第三军医大学学报

ABSTRACT

Objective To observe the clinical effect of non-invasive positive pressure ventilation(NIPPV) in the treatment of chronic obstructive pulmonary disease at acute exacerbation phase(AECOPD) combined with typeⅡrespiratory failure.Methods Fifty-three patients of therapeutic group were treated with NIPPV,as well as conventional therapeutic managements,such as antibiotic,pacifying gasp,eliminating phlegm,taking respiratory stimulants,and receiving continual low-flow oxygen.Whereas,53 controls only received conventional intervention.Results There was no significant difference between the 2 groups before the treatment,but significance was found in pH value,PaCO2,PaO2,HR and RR in them.The therapeutic group showed significantly improvement in PaCO2,RR and PaO2 compared with control group.Conclusion NIPPV intervention can effectively lower PaCO2 and RR,improve PaO2,shorten the course of hospitalization.