Analysis on Immune Effect of 10 Microgramme Recombinant Chinese Hamster Ovary (CHO) Cell HB Vaccine in Adults / 医学研究杂志

ABSTRACT

Objective To explore immune effects of HB vaccine and relative strategies of controlling hepatitis B in adults of different ages, genders, and different anti-HBs levels before immunization. Methods In Shaoxing city, 1055 healthy adults aged 18 to 50 with HBsAg negative were randomly selected and inoculated with 10?g/ml indigenous CHO HB vaccine according to the programme of 0,1,6 months. Results 835 adults completed the whole programme, and the total immunization coverage rate was 85.12%. Before and after immunization,the positive rates of anti-HBs were 52.10% and 98.44% respectively, and anti-HBsGMT rose from 14.32mU/ml to 413.98mU/ml. For the two groups, anti-HBsGMT=0 and 0