Relationship of interleukin-6 gene polymorphisms and its serum level with essential hypertension / 第三军医大学学报
Journal of Third Military Medical University
;
(24)2003.
Article
in Chinese
| WPRIM
| ID: wpr-562217
ABSTRACT
Objective To explore the relationship of interleukin-6 (IL-6) gene polymorphisms and its serum level with essential hypertension (EH) in Chinese Hans population and investigate the effect of IL-6 gene polymorphisms on serum IL-6 level. Methods The polymorphisms of IL-6 gene, -597 G/A, - 572 C/G and 174 G/C, were checked in 191 EH patients and 197 control subjects by PCR-RELP. Meanwhile their serum IL-6 level was determined by ELISA. Results Only -597 GG genotype and -174 GG genotype of IL-6 gene was found in the test population. There was significant difference in frequencies of - 572 genotype and allele between 2 groups. -572 CG+GG genotype and G allele were more frequent in patients than in controls (P
Full text:
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Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Third Military Medical University
Year:
2003
Type:
Article
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