The protective effect of high density lipoprotein on the liver function of rats with severe burns / 解放军医学杂志

ABSTRACT

Objective To explore the protective effect of high density lipoprotein on the liver function of rats with severe burns. Methods 135 Wistar rats employed in present study were randomly divided into control group (n=15, without treatment), burn group (n=60, with 30%TBSA full-thickness burn on the back) and experimental group (n=60, with the injection of 80mg/kg HDL via the caudal vein immediately after burns). The rats in the groups with burns injury were resuscitated with intraperitoneal isotonic saline (50ml/kg) 30 minutes after burn. The serum content of AST, ALT, ICAM-1 and TNF-? of the rats were determined with corresponding methods. The histological changes in the liver tissue of the rats in all groups were observed under light microscope and electronic microscope. Results The serum content of AST, ALT, ICAM-1 and TNF-? in the rats of control group were significantly lower than those in burn group (P