PROLIFERATION INHIBITION AND APOPTOSIS INDUCTION ON HUMAN HEPATO-CARCINOMA HepG-2 CELLS BY UNDARIA PINNATIFIDA POLYSACCARIDES / 营养学报

ABSTRACT

Objective: To investigate the inhibitory effect of Undaria pinnatifida polysaccharides (UPPS) on hepatocellular carcinoma HepG-2 cells and its possible mechanism. Method: The effect of inhibiting proliferation and inducting apoptosis of UPPS were determined by means of MTT and FCM. The expression of Bcl-2 and Bax proteins was immunohis to chemcally evaluated after treatment of UPPS. Results: UPPS inhibited HepG-2 cells growth in vitro , significantly higher than the negative control group (P