Protective effects of Cyclovirobuxine D on neonatal rat cardiomyocytes exposed to hypoxia-reoxygenation injury / 中国药理学通报
Chinese Pharmacological Bulletin
; (12)2003.
Article
in Zh
| WPRIM
| ID: wpr-562350
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WPRO
ABSTRACT
Aim To investigate the cardioprotective effects of Cyclovirobuxine D on pure cultared neonatal rat cardiomyoeytes exposed to hypoxia-reoxygenation (H/R) injury and the mechanisms. Methods The hypoxia/reoxygenation(H/R) injury model of pure cultured neonatal rat cardiomyocytes was developed.The concentration of lactate dehydrogenase (LDH) and malonialdehvde (MDA), the activity of super-oxide dismutes (SOD) and caspase-3, the apoptosis rate of cardiomyocyte were measured.Results Compared with the control group, the model group showed lower activity of SOD and higher concentrations of LDH , MDA, the apoptosis rate and activity of caspase-3(P
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WPRIM
Language:
Zh
Journal:
Chinese Pharmacological Bulletin
Year:
2003
Type:
Article