Cefepime for serious community acquired lower respiratory infection:44 cases report / 第三军医大学学报
Journal of Third Military Medical University
;
(24)2003.
Article
in Chinese
| WPRIM
| ID: wpr-562373
ABSTRACT
Objective To evaluate the efficacy and safety of cefepime in the treatment of serious community acquired lower respiratory infection. Methods Eighty-six patients of serious community acquired lower respiratory infection were randomized into the experimental group (n=44) receiving cefepime (2 g, intravenous infusion, twice a day) for 7-14 d and the control group (n=42) receiving cefotaxime (3 g, intravenous infusion, three times a day) for 7-14 d. Results There were no statistical differences of age, severity of the disease, original diseases, or distribution of pathogens between the two groups. In the experimental group, cefepime had a good therapeutic efficacy against not only the gram-negative bacteria infection and the gram-positive bacteria infection, but also other cephalosporin-resistant bacteria infection. Its cure rate was 86.4%, and effective rate 93.2%. In the control group, cefotaxime had a less therapeutic efficacy against the infection caused by some resistant strains of the gram-negative bacteria and the gram-positive bacteria. Its cure rate was 64.3%, and effective rate 76.2%. Conclusion The antibacterial activity of cefepime is stronger than that of cefotaxime. So cefepime is an effective and safe antibiotic, and suggested to use in the empirical treatment for serious community acquired lower respiratory infection.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Controlled clinical trial
Language:
Chinese
Journal:
Journal of Third Military Medical University
Year:
2003
Type:
Article
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