Effect of different compatibilities of effective fraction of Xie-Xin decoction on NF-?B and I?B expression of lung injury rats induced by LPS / 中国药理学通报
Chinese Pharmacological Bulletin
;
(12)2003.
Article
in Chinese
| WPRIM
| ID: wpr-562525
ABSTRACT
Aim To investigate the effect of effective fraction of Xie-Xin decoction and their compatibilities(EFX)on NF-?B and I?B expression of lung injury rats induced by LPS.Methods Rats were pretreated for 4 days with total flavones(TFL),total free anthraquinones(TFA),total conjugated anthraquinones(TCA),the high(low)dose of compatibility of TFL and TCA(A high,A low),the compatibility of TFL and TCA(B)and dexamethasone respectively 4 days,then injected intravenously with LPS to induce lung injury.6 rats were sacrificed respectively in every group at 1,2,4 h after LPS administration,and the right middle of the lung was harvested at every time point,the expression of NF-?B and I?B was evaluated by Western blot.Results TFA、A high and Dex can inhibit the nuclear translocation of NF-?B at 1,2,4 h(P
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Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmacological Bulletin
Year:
2003
Type:
Article
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