The Cinical Significance of Plasma Endothelin-1(ET-1) and Nitrous Oxide(NO) in Children Associated with Left to Right Shunt Congenital Heart Defect with Pulmonary Hypertension / 医学研究杂志

ABSTRACT

Objective To explore the cinical significance of Plasma Endothelin-1(ET-1) and Nitrous Oxide(NO) in the children associated with left to right shunt congenital heart defect(CHD) with Pulmonary Hypertension(PH).Methods 42 children associated with left to right shunt congenital heart defect with pulmonary hypertension(as patient's group),26 children associated with left to right shunt congenital heart defect without pulmonary hypertension(as heathly group),20 children had the checkup(as control group).Plasma ET-1 and NO2+/NO3+ was cletected in all groups by radioimmunoassay and nitric acid-restored method.Results ET-1 of patient's group was significantly higher than that of control group(P0.05);NO2+/NO3+ of that was significantly lower control group(P