THE COMPARATIVE STUDY ON EFFECTS OF GREAN TEA AND BLACK TEA POLYPHENOLS ON GENES RELATED TO ADIPOCYTE DIFFERENTIATION IN RATS / 营养学报
Acta Nutrimenta Sinica
;
(6)2004.
Article
in Chinese
| WPRIM
| ID: wpr-562635
ABSTRACT
Objective:
To compare the anti-obesity effect of green tea and black tea polyphenols and investigate their molecular mechanisms.Method:
Rats were divided randomly into four groupscontrol group,high-fat group,high-fat diet with green tea polyphenols(GTP) supplement group,and high-fat diet with black tea polyphenols(BTP) supplement group. Body weight was determined every 2 w. After 3 months,the changes of epididymal fat tissues weight and serum lipids were observed. Expressions of those genes associated with adipocyte differentiation in epididymal fat tissues of rats were measured by real-time transcription-polymerase chain reaction,including pref-1,aP2,TNF-?,leptin,PPAR-?,C/EBP-? .Results:
Both GTP and BTP prevented the increase of body weight and fat induced by high-fat diet and profoundly down-regulated those adipocyte-specific genes,including aP2,TNF-?and leptin. In addition,GTP also up-regulated the pre-adipocye marker — pref-1 and reduced the expression of transcription factor,peroxisome proliferators-activated receptor(PPAR-?) .Conclusion:
Tea polyphenols could prevent obesity by reversing the adipocyte differentiation,and GTP possessed stronger inhibitory effect than BTP.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Acta Nutrimenta Sinica
Year:
2004
Type:
Article
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