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EFFECT OF PHYTIC ACID ON EXPRESSIONS OF APOPTOSIS ASSOCIATED PROTEIN FAS、BAX AND CASPASE-3 IN SGC-7901 CELLS / 营养学报
Acta Nutrimenta Sinica ; (6)2004.
Article in Chinese | WPRIM | ID: wpr-562636
ABSTRACT

Objective:

To explore the effect of phytic acid on apoptosis of SGC-7901 cells and its mechanisms.

Method:

The inhibiting action of phytic acid on SGC-7901 cells was examed by MTT assay,and the effect on apoptosis of SGC-7901 cells was examined by DNA gel electrophoresis,and the expressions of Fas,Bax and caspase-3 protein were detected by Western blot method.

Results:

From MTT assay,we observed that phytic acid inhibited the growth of SGC-7901 cells in dose and time dependent manner. Typical DNA ladder was found during gel eletrophoresis. Caspase-3 can be activated by phytic acid and the expressions of Bax and Fas protein in phytic acid group were higher compared with control group,and increased in a dose-dependent manner.

Conclusion:

Phytic acid can induce apoptosis of SGC-7901 cells which may be correlated to apoptosis associated protein Fas,Bax and caspase-3.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Acta Nutrimenta Sinica Year: 2004 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Acta Nutrimenta Sinica Year: 2004 Type: Article