Glycogen synthase kinase-3:an emerging therapeutic target for Alzheimers disease / 中国药理学通报

ABSTRACT

Glycogen synthase kinase-3(GSK3)is a fascinating serine/threonine protein kinase which exists in cells generally.GSK3 activity is regulated by phosphorylation,protein complex formation,and its intracellular localization.GSK3 regulates many functions including cell survival and apoptosis,structure and motility,intracellular signaling pathways and so on.It is very important to keep the activity of GSK3.GSK3 has been linked to all of the primary abnomalities associated with AD.It is very important to study the inhibition of GSK3 as a therapeutic approach to treat AD.All the studies suggest that GSK3 is a promising therapeutic target for AD.