Expression of PC cell-derived growth factor and vascular endothelial growth factor in esophageal squamous cell carcinoma and their clinicopathologic significance / 中国实用内科杂志

ABSTRACT

Objective To investigate the expression of PC cell-derived growth factor(PCDGF or progranulin)and vascular endothelial growth factor(VEGF)and the relationships between them and clinicopathologic features in esophageal squamous cell carcinoma(ESCC),helping to determine the role of PCDGF(progranulin)and VEGF in angiogenesis.Methods The expression of PCDGF(progranulin)and VEGF in 50 surgical specimens from patients with ESCC and 20 with normal esophageal mucosa were detected by immunohistochemistry.The vascular endothelial cells in tumor tissue were labeled by antibody to CD105 for counting microvessel density(MVD).Results The expressions of PCDGF(progranulin)and VEGF in ESCC were obviously higher than normal mucosa.Their expression had positive correlation with depth of tumor invasion,lymph node metastasis,and TNM classification.In ESCC,both the expression level of PCDGF(progranulin)and VEGF had significant positive correlation with MVD and the expression of PCDGF had direct correlation with the expression of VEGF.Conclusion PCDGF marks tumor tissues with so high sensitivity that it can be a novel ESCC marker hopefully.The expression of both PCDGF(progranulin)and VEGF in ESCC has close relationship with angiogenesis,and they may take part in tumor growth,infiltration and metastasis through promoting tumor angiogenesis.