Effect of auricular needling on learning and memory and NMDAR1 in rats with vascular dementia / 中华中医药杂志

ABSTRACT

Objective: To observe the effect of auricular needling on abilities of learning and memory as well as expression of NMDAR1 in rats with vascular dementia(VD).Methods:VD rat model was established by blocking 4-vessel.The immunohistochemistry method was used to detect the changes of NMDAR1 expression,the Y-type maze test was used to measure the abilities of learning and memory.Results:There were slight expression of NMDAR1cells in the brain tissue of normal group.Compared with the normal group,the expression of NMDAR1 positive cells in model group were significantly enhanced,but the average optical density is obvious reduced(P