Study on antihyperlipidemia effect and acute toxicity test of piperlonguminine / 中华中医药杂志

ABSTRACT

Objective:To investigate the influence of piperlonguminine on blood-fat of animal and its acute toxicity. Methods:The hyperlipidemic model rats were established by feeding with the high-lipid diet for 14 days.Stomach-perfusion with piperlonguminine was accompanied at the same time.Effects of piperlonguminine on the hyperlipidemic rats were investigated by measurement of the contents of total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-c),high- density lipoprotein cholesterol(HDL-c).The hyperlipidemic model rabbits were established by feeding with hypercholesterol. The influences of piperlonguminine on serum lipid,liver lipid and atheroma were observed.The response of the acute toxicity of mice was also observed.Results:Piperlonguminine remarkably lowered the serum TC、TG、LDL-c,and increased the serum HDL-c of rats,lowered the serum TC、TG、LDL-c and liver TC、TG,and remarkably improved atheroma of rabbits.The acute toxicity was tested on mice.During the test there was no death.Even more it caused little pathological change.Conclusion: Piperlonguminine not only had significant antihyperlipidemia effects,but also improved atheroma effects.And the toxicity of piperlonguminine was very low.