Relationship among different types and subunits of calcium channels and antihypertensive drugs / 中国药理学通报
Chinese Pharmacological Bulletin
;
(12)1986.
Article
in Chinese
| WPRIM
| ID: wpr-563530
ABSTRACT
This paper elucidates the relationship among different types and subunits of voltage-gated calcium channels and antihypertensive drugs.①L-type calcium channels lack of functional expression in renal efferent arterioles,but it has been found recently that T-type calcium channels have had roles in the regulation of renal efferent arteriolar tone.Third generation dihydropyridine,L-type calcium channel antagonists including manidipine,nilvadipine,benzindamine and efonidipine,can dilate both afferent and efferent renal arterioles,then improve glomerular hypertension and provide renoprotection,because the inhibition of both L and T type calcium channels.② In hypertensive rats,an increased expression of L-type calcium channel ?1c subunits has been shown.and this increased expression of calcium channel ?1c subunit associated with the increase of Ca2+ influx and elevated arterial tone can be observed.These findings provide a rational basis for designing antihypertension therapy by normalizing Ca2+ channel ?1c subunit expression.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmacological Bulletin
Year:
1986
Type:
Article
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