The effect of vitamin C on hemodynamics and arterial blood gas in tourniquet induced ischemia-reperfusion injury during unilateral total knee replacement in elderly patients
Anesthesia and Pain Medicine
;
: 277-281, 2008.
Article
in Korean
| WPRIM
| ID: wpr-56368
ABSTRACT
BACKGROUND:
Free radicals, such as reactive oxygen species which are released abruptly after deflation of an ischemic tourniquet, cause reperfusion injuries. Vitamin C produce cytoprotective effects due to reduction of free radicals. This study was designed to investigate the effect of vitamin C on hemodynamics and arterial blood gas during unilateral total knee replacement.METHODS:
In the vitamin C group (VC group N = 19), patients were administrated with vitamin Ca priming bolus of vitamin C 0.06 g/kg mixed with 100 ml saline infused for 20 min at 10 min before deflation of tourniquet, followed by vitamin C 0.02 g/kg mixed with 30 ml saline at 0.5 ml/min. In the control group (control group N = 15), patients were infused by 100 ml saline. Mean arterial blood pressure, heart rate and arterial blood gas were measured at 20 min after anesthesia induction, just before deflation, 5 min after deflation and 20 min after deflation of tourniquet.RESULTS:
Mean arterial blood pressure in the VC group was maintained higher than control group at 1 min after deflation of the tourniquet. Arterial O2 tension and saturation in the VC group were higher than control group at 5 min and 20 min after deflation of the tourniquet.CONCLUSIONS:
We concluded that the administration of vitamin C during total knee replacement could inhibit decline of mean arterial blood pressure and arterial oxygenation induced by ischemiareperfusion significantly.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oxygen
/
Ascorbic Acid
/
Tourniquets
/
Vitamins
/
Reperfusion Injury
/
Reactive Oxygen Species
/
Arthroplasty, Replacement, Knee
/
Arterial Pressure
/
Free Radicals
/
Heart Rate
Limits:
Aged
/
Humans
Language:
Korean
Journal:
Anesthesia and Pain Medicine
Year:
2008
Type:
Article
Similar
MEDLINE
...
LILACS
LIS