Observations on short-term curative effect of resynchronization therapy for patients with chronic heart failure / 解放军医学杂志

ABSTRACT

Objective To observe the short-term curative effect of biventricular cardiac resynchronization therapy in patients with chronic heart failure.Methods Twenty-six patients with chronic heart failure underwent biventricular cardiac resynchronization therapy,and a left ventricle lead was implanted from the coronary sinus to vein.During the 3-34(13.8?10.4)months of follow-up period,the following parameters were recordedthe cardiac function,patients' activity,heart rate at night,QRS wave width,left ventricular end-systolic dimension(LVESD),left ventricular end-diastolic dimension(LVEDD),end-systolic volume(ESV),end-diastolic volume(EDV),left ventricular ejection fraction(LVEF),left ventricular filling time,and standard deviation of time to regional peak systolic velocity(Ts-Sd-12).Results One out of the overall 26 patients died from sudden cardiac death.The cardiac function was improved in the 25 survivals in the 3-months follow-up,showing that the effective rate of CRT was 96.2%.For the 25 patients,the cardiac function was improved according to New York Heart Association(NYHA)functional class from Ⅲ-Ⅳ grade to Ⅱ-Ⅲ grade.The average total activity time was increased from 0.31?0.40 hours per day to 2.35?1.20 hours per day.Average heart rate during night-time was decreased from 84.8?15.7 beats per minute to 63.4?4.5 beats per minute,variability of cardiac rhythm was raised from 47.3?7.1ms to 96.4?15.1ms;QRS duration was shortened from 158.6?31.8ms to 129.5?30.2ms(P