Studies on resuscitation of hemorrhagic shock canine via cavum ossis infusion of hypertonic saline solution / 解放军医学杂志

ABSTRACT

Objective To study the resuscitation effect of cavum ossis infusion of hypertonic saline solution on hemorrhagic shock canine,and investigate the corresponding internal microenvironment changes.Methods Eighteen healthy Wiggers dogs weighed 16-19kg were adopted in present study and assigned into three groups(6 each) group HSH,group NS and group Sham.Hemorrhagic shock canine model was established.Dogs in HSH group received a rapid cavum ossis infusion with 7.5% hypertonic resuscitation solution(sodium chloride + 6% hydroxyethyl starch),and the dogs in group NS was only given 7.5% sodium chloride solution,while the dogs in Sham group were treated by general anaesthesia,assisted respiration with breathing machine and without bleeding and transfusion.Changes of central venous pressure(CVP),mean arterial pressure(MAP),intramedullary pressure(IMP),and the levels of blood lactate and sodium were monitored during the resuscitation phase.Results During hemorrhagic shock stage,the haemodynamic parameters MAP,CVP and IMP in groups HSH and NS decreased significantly,while blood lactate significantly increased at each time point as compared with that in group Sham(P0.05).The lactate level during resuscitation phase in group HSH decreased significantly as compared with that during hemorrhagic shock stage(P