Effect of two colloidal fluids on red blood cell immune function in dog model of hemorrhagic shock / 第三军医大学学报

ABSTRACT

Objective To observe the therapeutic efficacy of 6% hydroxyethyl starch 130/0.4 (trade name voluven) and polygeline on dog with hemorrhagic shock and their effect on immune function of red blood cells (RBC). Methods Eighteen dogs were randomized into three groups (n=6 in each group) normal sodium group, voluven group and polygeline group. Hemorrhagic shock models were set up according to Wiggers’ method. The mean arterial pressure value was bled to (45.56?3.69) mmHg within 10 min and maintained at this level for 60 min. Subsequently the dogs were resuscitated with normal saline or voluven or polygeline. The hemodynamics were measured before and 60 min after shock and 10, 30 and 60 min after infusion. The concentrations of MDA in plasm, C3b receptor garland rate (RBC-C3bRR) and RBC immune complexes garland rate (RBC-ICR) were measured. Results At 60 min after shock, MAP and CO were significantly lower than these before shock (P