Validation of a Scoring System for Predicting Malignancy in Patients Diagnosed with Atypical Ductal Hyperplasia Using an Ultrasound-Guided Core Needle Biopsy / 한국유방암학회지
Journal of Breast Cancer
;
: 407-411, 2012.
Article
in English
| WPRIM
| ID: wpr-56438
ABSTRACT
PURPOSE:
The need for surgical excision in patients with ultrasound-guided core needle biopsy (CNB)-diagnosed atypical ductal hyperplasia (ADH) remains an issue of debate. The present study sought to validate a scoring system (the U score, for underestimation) that we have previously developed for predicting malignancy in CNB-diagnosed ADH.METHODS:
The study prospectively enrolled 85 female patients with CNB-diagnosed ADH who underwent subsequent surgical excision. Underestimation was defined as a surgical specimen having malignant foci.RESULTS:
The overall underestimation rate was 37% (31/85). Multivariate analysis showed that a clinically palpable mass, microcalcification on imaging, size >15 mm and a patient age of > or =50 years were independently associated with underestimation. When applied to the scoring system, the validation score was significant (p<0.001; area under the curve, 0.852). No patient with a U score <3.5 had an underestimated lesion.CONCLUSION:
The present study successfully validated the efficacy of our scoring system for predicting malignancy in CNB-diagnosed ADH. A U score of < or =3.5 indicates that surgical excision may not be necessary.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Biopsy, Needle
/
Breast Neoplasms
/
Multivariate Analysis
/
Prospective Studies
/
Diagnostic Errors
/
Biopsy, Large-Core Needle
/
Hyperplasia
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
Limits:
Female
/
Humans
Language:
English
Journal:
Journal of Breast Cancer
Year:
2012
Type:
Article
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