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Effect of Shengmai capsules on MMP-3&TIMP-1 of cardiac muscle in rats with chronic congestive heart failure / 中华中医药杂志
Article in Zh | WPRIM | ID: wpr-564434
Responsible library: WPRO
ABSTRACT
Objective:To research the effect of Shengmai capsules on the matrix metalloproteinase(MMPs)& tissue inhibitor of metalloproteinase(TIMPs)in chronic congestive heart failure(CHF)rats.Methods:75 SD female rats weredivided randomly into 5 groups:sham-operation group(A),CHF model group(B),CHF model treated by Shengmai capsules group(Shengmai capsule group,C),CHF model treated by Captopril group(Captopril group,D),CHF model treated by Shengmai capsule and Captopril group(shengmai capsule&captopril group,E),15 rats each group.Suprarenal abdominal artery constriction was operated to prepare CHF rat models.After 7 week treating respectively,the contents of MMP-3&TIMP-1 of cardiac muscle in rats were detected.Results:The content of cardiac MMP-3 was higher in group B than in group A(P
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Full text: 1 Index: WPRIM Language: Zh Journal: China Journal of Traditional Chinese Medicine and Pharmacy Year: 2005 Type: Article
Full text: 1 Index: WPRIM Language: Zh Journal: China Journal of Traditional Chinese Medicine and Pharmacy Year: 2005 Type: Article