The Effect of Erythromycin on Nuclear Factor Kappa B and Intercellular Adhesion Molecule-1 in Airway Epithelium of Smoking Rat / 医学研究杂志

ABSTRACT

Objective To explore the anti-inflammatory therapeutic role of erythromycin in chronic obstructive pulmonary disease(COPD) by investigating the effect of erythromycin on the level of nuclear factor kappa B(NF-?B) and intercellular adhesion molecule-1(ICAM-1) in airway epithelium of smoking rats.Methods Wistar rats(n=30)with weighed(150?10) g each,20 were randomly sampled to be exposed to cigarettes smoking for four weeks then 10 of them were exposed wntinuously to cigaretts smoking for eight weeks as smoking,group,other loof them were intragastrically perfused by erythromycih before smoking as evythromycin group,the rest of total 30 rats as control group Then assessed expiratory airway resistance and lung compliance and observed the expression level of NF-?B and ICAM-1 in airway epithelium by using immunohistochemical method.Results(1) The expiratory airway resistance was increased and the lung compliance was degraded significantly in smoking group(5.67?0.32,4.39?0.40)(P