Inhibitive and toxic effects of artesunate on murine bone marrow hematopoietic stem and progenitor cells / 中国临床药理学与治疗学
Chinese Journal of Clinical Pharmacology and Therapeutics
;
(12)2004.
Article
in Chinese
| WPRIM
| ID: wpr-564744
ABSTRACT
AIM:
To observe the influences of artesunate(AS)on murine bone marrow hematopoietic stem and progenitor cells.METHODS:
Murine bone marrow hematopoietic stem and progenitor cells were cultured in vitro with different concentration of AS.The numbers of erythrocyte colony-forming unit(CFU-E)or burst-forming unit(BFU-E)in liquid or semisolid culture were counted through light microscope.Apoptosis of cultured cells and the changes of mitochondrial membrane potential were detected by flow cytometry(FCM)analysis,meanwhile,DNA ladder gel electrophoresis were conducted.RESULTS:
AS could significantly inhibit the formation of CFU-E and BFU-E(P
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Clinical Pharmacology and Therapeutics
Year:
2004
Type:
Article
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